The Kansas City Chiefs might have claimed their second win of the season but the alarm bells are ringing after their lead running back, Isiah Pacheco, left the game with an injured ankle.

Pacheco rushed for 90 yards on 19 carries and added an extra 21 yards from five catches in an impressive performance for the Chiefs as the defeated the Cincinnati Bengals 26-25 at the Arrowhead Stadium.

But despite the upturn in form, it appears he will be sidelined for Week 3 after sustaining an ankle injury in the fourth quarter, although head coach Andy Reid admitted they don’t know the extent of it.

“The only major injury would be (Isiah) Pacheco with his ankle,” Reid said, per A to Z Sports. We’ll just have to see.

“He’s having some tests done on it now, x-rays, all that stuff. So I don’t have anything for you exactly what it is, but he came out with the ankle.”

Jeff Darlington later posted to X.com, formerly Twitter, that Pacheco was also spotted leaving the stadium after the victory in crutches and a walking boot meaning the 25-year-old appears to have been seriously hurt.

Mahomes struggles against Bengals

Pacheco was perhaps the only positive to come out of the game against the Bengals, on a night when the Chiefs and Patrick Mahomes struggled against Joe Burrow‘s team although they did manage to secure the win.

Mahomes, chasing a third straight Super Bowl, threw for 151 yards and two touchdowns but gave up two interceptions and maintained a pass completion rate of 72% from 25 attempts, although this was helped by numerous calls of pass interference against the Bengals.

Meanwhile Burrow threw for 258 yards and two touchdowns from 36 attempts (63.8%) as he led his team to the bring of a key win in the 2024/25 NFL season before Harrison Butker ensured the Bengals left empty handed.