Caitlin Clark and Peyton Manning have teamed up for a lighthearted and memorable new commercial showcasing their comedic timing and love for Indianapolis.

Released on Wednesday, the ad quickly gained traction on social media, drawing laughs and praise from fans of both sports icons.

In the commercial, Manning is seen attempting to perform surgery while Clark watches in amused disbelief.

As they discuss the exceptional skill of the surgeons at Ascension St. Vincent Hospital in Indianapolis, Clark questions Manning‘s apparent attempt at heart surgery.

Yet, Manning isn’t working on a human heart-he’s stitching up a teddy bear.

Indianapolis icons unite

The pairing of Manning and Clark makes perfect sense, as both athletes are deeply tied to Indianapolis and its sports culture.

Manning, one of the most legendary quarterbacks in NFL history, spent 13 seasons with the Indianapolis Colts and remains a beloved figure in the city.

His name is prominently featured at the Peyton Manning Children’s Hospital, part of Ascension St. Vincent Hospital.

Meanwhile, Clark is rapidly becoming a household name in Indiana as a star with the Indiana Fever.

Her meteoric rise in basketball, combined with her local impact, has made her one of the most celebrated athletes in the region. Together, the two represent the past and present of Indianapolis sports excellence.

Unsurprisingly, the ad has garnered significant attention online, with fans praising the duo’s chemistry and humor.

“Caitlin Clark and Peyton Manning in one commercial? Indianapolis just won the ad game,” one user posted on X.

Another fan commented: “The teddy bear reveal was hilarious-Manning and Clark nailed it!”

The campaign not only reinforces Ascension St. Vincent’s commitment to care but also celebrates the legacy and future of sports in Indianapolis.