It looks like the biggest break yet in the Nancy Guthrie kidnapping … Pima County deputies swarming a home in the Tucson area, and apparently, taking 2 people into custody.

The Sheriff’s Department’s SWAT unit rolled out Friday night in the rain with a huge show of force … first reported by NewsNation’s Brian Entin, whose crew got the video of cops walking out with a man and woman.

It’s unclear if they are suspects or persons of interest … or if they’ve been arrested — but, law enforcement has a search warrant related to the Guthrie case, according to Entin.